|
KMID : 0931320120120020096
|
|
대한상부위장관.헬리코박터학회지
2012 Volume.12 No. 2 p.96 ~ p.102
|
|
|
Changing Trends of Serum Pepsinogen I/II Ratio in Asymptomatic Subjects
|
|
Yang Jae-Hoon
Lee Sun-Young
Hong Sung-Noh
Kim Jeong-Hwan
Sung In-Kyung
Park Hyung-Seok
Shim Chan-Sup
Jin Choon-Jo
|
|
|
Abstract
|
|
|
Background/Aims: Gastric atrophy can be diagnosed by serum pesinogen I/II ratio. The aim of this study was to investigate whether the changes of serum pepsinogen I/II ratio can be predicted by gastroscopy.
Materials and Methods: Sixty healthy subjects who underwent screening for serum pepsinogen I/II levels, serum Helicobacter pylori (H. pylori) antibody, and gastroscopy for two sequential years were included. Endoscopic findings were classified into four different categories according to the degree of chronic atrophic gastritis; none, mild, moderate, and severe. Changes of the serum pepsinogen I/II ratio, body mass index, H. pylori antibody, and endoscopic findings were analyzed after a year.
Results: The serum pepsinogen I/II ratio showed a tendency to decrease after a year in subjects with H. pylori infection (P=0.013) and those with moderate to severe atrophic gastritis (P=0.004), whereas it increased in subjects without H. pylori infection and those with none to mild atrophic gastritis. On multivariate analysis, the degree of atrophic gastritis was the only factor that was related to the changing trends of the serum pepsinogen I/II ratio (odds ratio=5.385, P=0.023).
Conclusions: The degree of atrophic gastritis on endoscopic findings can predict the changes of the serum pepsinogen I/II ratio after a year. Regardless of the current status of H. pylori infection, the serum pepsinogen I/II ratio decreases after a year in subjects with moderate to severe atrophic gastritis.
|
|
|
KEYWORD
|
|
|
Gastritis, atrophic, Helicobacter pylori, Gastroscopy, Pepesinogens
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|